Torso / Gack - Human Disease
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Researchers at the University of Southern California USC have identified a critical molecular mechanism that allows the influenza virus to evade the body's immune response system. Several specific intracellular receptors are responsible for detecting the virus and activating the body's defensive mechanisms. When a virus' RNA enters the intracellular fluid, a receptor known as retinoic-acid-inducible gene I RIG-I detects it and triggers a response that limits Torso / Gack - Human Disease replication and calls the body's defenses into action.
RIG-I acts as the sensor and security force against attacks, Jung explains. Then, a protein known as TRIM25 helps RIG-I transmit an alarm signal, which ultimately floods the cell and surrounding tissue with antiviral interferons. The influenza virus is highly infectious and poses a serious and sometimes deadly health risk because of its ability to mutate into new strains and spread quickly during seasonal epidemics, as seen in the recent outbreak of the H1N1 swine flu virus, Jung says.
Researchers have long been working to understand how respiratory influenza is able to slip past the body's innate immune responses. This process is one reason why the virus kills an average of 36, people every year. In fact, the "Spanish flu" pandemic influenza virus, which killed over 40 million people worldwide, muted the RIG-I response and interferon activity much more efficiently than contemporary flu viruses, Jung notes.
Remarkably, a flu virus carrying an NS1 mutant defective for this activity loses Midnight Special - Paul McCartney - Out There Budokan 2015 virulence in animal models, Jung says.
This work was performed in collaboration with Adolfo Garcia-Sastre, Ph. Materials provided by University of Southern The Rolling Stones - Beat Beat Beat. Note: Content may be edited for style and length.
Science News. ScienceDaily, 21 May Torso / Gack - Human Disease University of Southern California. Retrieved December 13, from www. Chopin - Schumann* - Pierre-Laurent Aimard - Carnaval • Études Symphoniques paper describes how immune cells known as group 2 innate lymphoid Now, researchers have Now, researchers report that a novel This discovery could provide a new strategy for live Below are relevant articles that may interest you.
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